Here’s your post rewritten with an active, scientific voice and in cohesive paragraph format:
Proper nutrition plays a critical role in maintaining health and preventing disease, including colorectal cancer (CRC). Colorectal cancer arises through three primary pathways: the adenoma–carcinoma sequence via chromosomal instability (50–70%), the mismatch repair deficiency pathway associated with Lynch syndrome (3–5%), and the serrated pathway (30–35%). The World Health Organization classifies serrated polyps into three distinct lesions: hyperplastic polyps (HP), sessile serrated adenomas/polyps (SSA/P), and traditional serrated adenomas (TSA).
Although the precise causes of these growths remain incompletely understood, emerging evidence challenges long-held assumptions about calcium supplementation. A large study led by Dr. Seth D. Crockett and colleagues at the University of North Carolina examined more than 2,200 individuals who had undergone polyp removal by colonoscopy. Participants received calcium supplementation for 3–5 years followed by an additional 3–5 years of observation. The investigators reported that calcium supplementation alone more than doubled the risk of developing serrated sessile adenomas/polyps (SSA/Ps), and combined calcium with vitamin D supplementation increased the risk more than fourfold.
These findings stand in contrast to the long-standing belief that dietary calcium protects against colorectal polyps and cancer. While calcium and vitamin D may still confer benefits in other physiological domains, this study underscores the need for individualized risk–benefit assessment, particularly in populations with elevated risk, such as smokers. Patients should consult their primary care physician to determine appropriate dietary calcium intake and avoid over-reliance on supplements as a preventive strategy.
Would you like me to make this even more concise for a professional social media post, or keep it structured for something like a medical blog article?
